Summary
The ten challenges of Bioinformatics
- Precise models of where and when transcription will occur in a genome (initiation and termination)
- Precise, predictive models of alternative RNA splicing
- Precise models of signal transduction pathways
- Determining protein:DNA, protein:RNA, protein:protein recognition codes
- Accurate ab-initio protein structure prediction
- Rational design of small molecule inhibitors of proteins
- Mechanistic understanding of protein evolution
- Mechanistic understanding of protein speciation
- Development of effective gene ontologies
- Education: development of bioinformatics curricula