Computational Structural Biology at Davis (CSBD)
Our research program focus on understanding macromolecular structures. We are interested in characterizing their shapes, and use this information to improve our understanding of their stability. We are also interested in characterizing the subset of sequence space compatible with a protein or nucleic acid structure: this is an indirect approach to understanding sequence evolution, both at the RNA and protein level. In parallel, we are involved in the development of new algorithms for predicting the structure of a protein, based on its sequence.
Some of our current projects:
- Developing a Structural Alphabet for protein structures
- Geometric representation of sequences
- Geometry of protein-protein interactions (with Joel Hass, UC Davis, Nina Amenta, UC Davis)
- Protein sequence design
- Homology modeling
- Normal mode dynamics (with Marc Delarue, Institut Pasteur, Paris)
- Electrostatics calculations (with Marc Delarue, Institut Pasteur, Paris)
- Ontology of multiple sequence alignment (with Julie Thompson and Olivier Poch, IGBMC, Strasbourg, France)
Information about lab members and visiting scholars Read more...
Curent lab members
- Patrice Koehl, Ph.D.: Associate Professor UC Davis Genome Center Department of Computer Science College of Engineering. Read more...
- Xinwei Shi, Ph. D.: Post Doc Read more...
- Eric di Luccio, Ph. D: Post Doc Read more ...
- Marie-Christine Vallet: Software developer Read more...
- Patricia Francis-Lyon: Graduate student Read more...
- Paul Mach: Graduate student Read more...
- Dave Gae: Graduate student
- Eric Willgohs: Graduate student
- Euisung Kang: visiting scholar Read more ...